Posts Tagged ‘PET’

PET scans show Transcendental Meditation with cardiac rehabilitation increases blood flow to the heart

December 5, 2019

EurekAlert! Summary: Study finds coronary heart disease (CHD) patients who include Transcendental Meditation (TM) with cardiac rehabilitation (CR) increased blood flow to the heart by 20.7%. This was the first study to show TM significantly enhanced lifestyle modification in patients, and the first to use positron emission tomography (PET) to measure their effect on cardiac function and rehabilitation. The NIH-funded study was conducted at Columbia University Irving Medical Center in collaboration with the Institute of Prevention Research. See EurekAlert! Press Release.

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Can more be done besides diet and exercise to better recover from a heart attack, a stroke, or to prevent one? Scientists from Columbia University Irving Medical Center and the Institute for Prevention Research conducted a study, with and without meditation, to find out.

The study, published in the Journal of Nuclear Cardiology, found that patients with coronary heart disease who included Transcendental Meditation (TM) with their cardiac rehabilitation regime increased blood flow to the heart by more than 20%.

Titled “Effects of cardiac rehabilitation with and without meditation on myocardial blood flow using quantitative positron emission tomography”, the pilot study was funded by the National Institutes of Health and conducted at Columbia University Irving Medical Center, in collaboration with the Institute for Prevention Research. The research involved 56 patients who had coronary heart disease, including recent heart attack, coronary artery bypass, or angina.

First study of its kind

The project was a groundbreaking proof-of-concept study, in that it was the first to combine Transcendental Meditation with other lifestyle treatment modalities, and the first to use positron emission tomography (PET) to measure the effect of lifestyle mind-body modification on cardiac function.

“This was the first study to show that the cardiovascular benefits of lifestyle modification such as structured exercise and dietary counseling may be enhanced by adding Transcendental Meditation in patients with heart disease,” said Robert Schneider, MD, FACC, co-director of the study and medical director of the Institute for Prevention Research. “It also found that the Transcendental Meditation technique alone was able to reverse the effects of coronary heart disease assessed by PET imaging.”

Considered a gold standard for measuring myocardial flow reserve non-invasively, cardiac PET has diagnostic and prognostic significance in coronary heart disease.

Randomized, controlled pilot study

The researchers randomly divided the subjects into four groups: cardiac rehabilitation, Transcendental Meditation, Transcendental Meditation plus cardiac rehabilitation, or usual care.

The results showed that of the 37 patients who completed posttesting, myocardial blood flow increased by 20.7% in the group that did both Transcendental Meditation and cardiac rehabilitation. Blood flow in the group that practiced Transcendental Meditation alone increased 12.8%. Cardiac rehabilitation by itself showed an improvement of 5.8%. And patients who received the usual treatment showed a decrease in blood flow of -10.3%. Also see graph of Changes in myocardial flow reserves for the combined TM and non-TM groups.

Stress reduction therapies in cardiac rehabilitation

“Although this is a preliminary study, it suggests that managing one’s mind-body connection with Transcendental Meditation can improve the function of the heart in cardiovascular patients,” said Dr. Schneider, who is also dean of Maharishi University of Management’s College of Integrative Medicine.

He said that psychosocial stress is known to be a risk factor for coronary heart disease but that stress reduction therapies aren’t usually included in cardiac rehabilitation.

“More research needs to be done, but this study and previous research strongly suggest that medical professionals should consider utilizing this simple yet effective mind-body intervention in their heart health treatment and prevention programs,” Dr. Schneider said.

Possible mechanism

While it’s not known precisely how Transcendental Meditation would increase blood flow, the researchers speculate that it’s a result of improved endothelial-mediated coronary and arteriolar vasomotor function. That is, reduced levels of stress hormones and possibly inflammation may result in improved function of the endothelial cells that line the coronary arteries. They cite research, which has found that modifying risk factors for cardiovascular disease improves blood flow in the heart.

Limitations of the study

While the study suggests that the Transcendental Meditation technique can increase blood flow in cardiovascular patients, carefully conducted clinical trials with larger sample sizes are needed to confirm the benefit.

“This was a first pilot study designed to determine the size of the effect and feasibility,” Dr. Schneider said. “Of the 56 original subjects, only 37 were available for the final posttesting of blood flow after the 12-week study period. In addition, compliance with cardiac rehabilitation was average, with attendance at exercise sessions about 60%. Also, the subjects practicing Transcendental Meditation may have received more attention than the rehabilitation group. This initial study paves the way for full scale clinical trials that will more rigorously evaluate these effects.”

Transcendental Meditation also reduces risk factors for heart disease

Earlier studies have shown that the Transcendental Meditation technique reduces risk factors for cardiovascular disease, such as blood pressure, atherosclerosis, and insulin resistance. A 2012 study found a 48% reduction in heart attack, stroke, and death.

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Effects of cardiac rehabilitation with and without meditation on myocardial blood flow using quantitative positron emission tomography: A pilot study https://doi.org/10.1007/s12350-019-01884-9.

PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31529385.

Some News Coverage

Within 4 days of posting the press release there were well over 12,000 page views on EurekAlert! Some significant science news websites that reported on the study were HealthImaging: Meditation increases blood flow in the heart, PET scans show; and PsychCentral: Transcendental Meditation with Cardiac Rehab Can Increase Blood Flow to Heart.

Gary Null discussed the need for prevention on his show’s podcast and shared news of newly published natural approaches for improving heart health. He included MUM’s study at CUIMC from 26:28 to 27:10.

Related: New study shows Transcendental Meditation prevents abnormal enlargement of the heart, reduces chronic heart failure risk

January 24, 2020, Thrive Global published: Manage Your Mind to Manage Your Heart: Why Transcendental Meditation is Vital for Heart Health. Research studies show regular TM practice reduces risk factors for cardiovascular disease. By Robert Schneider, M.D., FACC, Dean, College of Integrative Medicine, Maharishi International University.

Can stress-reducing Transcendental Meditation help CHD patients prevent future heart attacks?

November 6, 2009

EurekAlert! Banner

Public Release: 6-Nov-2009

Can stress-reducing Transcendental Meditation help CHD patients prevent future heart attacks?

The National Institutes of Health’s National Heart, Lung, and Blood Institute will fund a $1 million collaborative study by the Center for Natural Medicine and Prevention at Maharishi University of Management Research Institute and Columbia University Medical Center to determine whether the stress-reducing Transcendental Meditation technique can help patients with coronary heart disease (CHD) prevent future heart attacks, strokes and death.

The 12-week “Randomized Controlled Trial of Stress Reduction in the Secondary Prevention of Coronary Heart Disease in African Americans,” will be conducted at Columbia University Medical Center in New York City. The trial will examine 56 patients who have had a heart attack or bypass surgery, angioplasty, or chronic angina.

“For decades, stress has been implicated in the cause and progression of heart disease,” said Robert Schneider, M.D., F.A.C.C., lead author and director of the NIH-funded Center for Natural Medicine and Prevention. “And while standard cardiac rehabilitation usually includes supervised exercise and lifestyle education, it does not usually include a formal stress reduction program.

“Now, for the first time, this study will evaluate whether adding stress reduction through the Transcendental Meditation technique to conventional cardiac rehabilitation will aid in the treatment of serious CHD compared to conventional cardiac rehabilitation alone,” Dr. Schneider said.

Patients will be carefully evaluated before and after the study for changes in their coronary artery disease with the most advanced noninvasive methods for measuring cardiac function—PET or positron emission tomography. According to Sabahat Bokhari, MD, Director of Nuclear Cardiology at Columbia University Medical Center and study co-director, “PET is an innovative imaging technology that allows us to visually and non-invasively study blood flow to the heart. With this state-of-the-art technology, doctors can now measure the blood flow to the heart and thus quantify the full impact of stress reduction on CHD.”

The NIH funding allocation is part of the Obama Administration’s American Reinvestment and Recovery Act—or economic stimulus bill. Competition for the funding was fierce with more than 20,000 applications for the Challenge Grants category and only 840 awarded. “In the current climate of health care reform, the purpose of this grant is to find more effective treatments for heart disease and thereby find more effective ways to reduce health care costs,” Dr. Schneider said.

“The NHLBI’s Recovery Act funds will make it possible to evaluate Transcendental Meditation as a promising tool in helping to prevent heart attacks, strokes, and death related to coronary events. This is worthwhile research since we know that strong emotional stress can lead to conditions such as arrhythmia and hypertension,” said NHLBI Director Elizabeth Nabel, M.D.

Results from several earlier trials on the Transcendental Meditation program found reductions in risk factors for heart disease, such as hypertension, psychological stress, insulin resistance, and build-up of atherosclerosis in the arteries, with indications of reduced mortality from heart disease. This newly funded study will directly evaluate coronary artery disease and continue to examine the potential of meditation for improvements in cardiovascular health.

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Fast Facts on Coronary Heart Disease:

  • Coronary heart disease (CHD) is the leading cause of death in the United States
  • There are nearly 1.5 million heart attacks per year in the US, according the American Heart Association
  • An American will suffer a heart attack every 34 seconds
  • Coronary heart disease is also the leading cause of soaring health care costs; more than $475 billion spent annually on treating CHD, including
    • $100,000 for each coronary bypass surgery
    • $50,000 for each angioplasty
    • $30,000 for each diagnostic cardiac catheterization
  • There are nearly 500,000 coronary artery bypass grafts and 1.3 million angioplasties performed every year
  • Stress is thought to contribute to development of CHD

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